I've tried to work around it. I really have, but man, there are times the opposed buttons are my undoing. Which buttons? The volume and wake/sleep buttons are opposite each other. The volume buttons serve as great, physical shutter buttons for the iPhone's camera. Most of the time.
With the iPhone 6, they frequently aren't. Imagine, waiting for the exact moment. You've set up the shot and you're simply bidding your time. There it is. Click.
Instead of capturing it, the phone goes dark. It's annoying.
Clip from Ronin, a fantastic and underappreciated film you should check out. If you want a a bigger taste right this minute the whole scene is solid.